Solving the technical problems and shortening the gap between China's spray drying equipment and foreign countries
With the rapid and rapid development of China's economy, the demand for new drying technologies has been increasing. However, in terms of China's current progress in drying technology, the overall level of technology is still lagging behind. It is difficult to meet the related industries due to economic development and products. Optimize the structure and new product development needs. Most of the pharmaceutical, biochemical, and fine chemical industries in China use vacuum-entrained heating to produce dry materials that are easy to oxidize and contain organic solvents. The innovative application of air-jet spray drying equipment uses nitrogen as a conductive heat transfer medium. At the same time, it adopts closed-circuit circulation technology and combines with continuous spray-drying spray drying to solve the problem of liquid materials containing organic solvents and dry refractory oxides. At the same time, in the continuous drying process, the use of condensing cooling technology to achieve the recycling of organic solvents, on the basis of achieving emission reduction of industrial production, demonstrates the circular economy of maximizing resource utilization. For many years, the processing methods and processing equipment of domestic drying equipment have also taken more traditional manual manufacturing, and spray drying equipment still has many deficiencies. Experts believe that if we want to shorten the gap with foreign countries, our country will only begin to improve the intelligence, processing methods, and processing quality of the equipment. The author was informed that the spray drying machine technology of Changzhou Changjiang Drying Equipment Co., Ltd. refers to the method of spraying to disperse the materials in a hot air current in the form of droplets. The materials are in full contact with the hot gas and the process of heat transfer and mass transfer is completed in an instant. The solvent is quickly evaporated into a gas to achieve the purpose of drying. This technology can eliminate evaporation, crystallization, separation and crushing unit operations, can be continuous, automated production, stable operation. With this drying method, the gas-solid two-phase contact surface area is large and the drying time is short, generally 5 to 30 seconds, and is suitable for drying heat-sensitive materials. The dried product has good performance, the available fine particles are small, and the product has good flowability and fast dissolvability. However, it still has certain disadvantages, that is, the size of the dryer is large and the heat transfer coefficient is low, resulting in low thermal efficiency and large power consumption. The future development of the spray dryer will be in-depth study of the drying mechanism and material drying characteristics, master the optimum operating conditions for different materials, develop and improve the spray dryer. In addition, large-scale, high-strength, high-economy, and improved adaptability to raw materials and product quality are the basic trends in the development of spray dryers. At the same time, the development of spray dryers should also pay attention to energy-saving and energy comprehensive utilization, as well as the development of automatic dryer control technology to ensure the realization of optimal operating conditions. The pharmaceutical industry is different from the general production industry. The requirements in all aspects are relatively more demanding. For production companies, the selected production equipment must also meet many standards and requirements. The requirements for the relevant pharmaceutical spray drying equipment are also very demanding. According to relevant industry sources, in order to meet production standards, pharmaceutical companies need to pay close attention to the following issues when selecting spray drying equipment: First of all, when purchasing a pharmaceutical spray dryer, it is necessary to consider whether it will cause problems such as contamination of production items. All the places that come in contact with materials and hot air must be made of stainless steel. In order to prevent contamination of the products, The stainless steel grade used should also meet the pH of the pharmaceutical material. Second, when purchasing a pharmaceutical spray dryer, it is necessary to consider whether it can meet the requirements for hygienic quality in production. In actual production, the air entering the tower may be required to be purified before being used. In addition, the operating state of the drying tower should be maintained at a slightly positive pressure. The finished product is output at the bottom of the cone of the drying tower, and then the finished product is collected and packaged in a clean room. Third, the issue to be considered is whether to meet the requirements for environmental protection. As a production company, this is also an important aspect. When using a special spray dryer, the company should also be equipped with a corresponding dust removal equipment, so that the exhaust emission concentration standard can be achieved. Finally, when a pharmaceutical spray dryer is used, it must be ensured that the equipment has a good sealing effect and will not bring new sources of pollution. The inner wall is also smooth and flat. The structure should also be as simple as possible, easy to clean, and reliable in operation. With the development of the national economy, people's requirements for the improvement of the quality of life are not only required for many products to be dried, but also for the color, aroma, taste, reconstitution (cold or instant) of the final product, vitamin activity retention rate, etc. Putting forward higher requirements, the total yield of some valuable drugs is also very harsh. Therefore, in the R&D and production of spray-drying equipment companies, it is necessary to continuously promote technological innovation and produce products that meet the requirements in accordance with market demand. In addition, as people attach importance to environmental protection, improving the environmental protection measures of spray dryers to reduce the leakage of dust and exhaust gas will also be the direction that companies need to study in depth.
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